Cases
SEKELS MAGμMAN
arrow_backTo the overview14 September 2023 | SEKELS GmbH
Permanent magnetic tool for contactless
guiding of magnetic particles
Nanoparticles gain more and more importance in biological and pharmaceutical research. In many fields, the controlled contactless motion of ferromagnetic nanoparticles is of great importance.
Examples are cell manipulation, cell sorting, magnetic drug targeting (MDT), hyperthermia and motion of suspended cells doped with nanoparticles. Due to the dynamic evolution of this field of research, this enumeration can only be regarded as an extraction.
Move suspended iron oxide
nanoparticles (SPIONs)
along arbitrary trajectories
Observe nanoparticles under most
commercially available
microscopes
Program particle movements with
supplied software
Features
- permanent magnet based
- intended for experiments in a Petri dish
(ibidi Glass Bottom Dish 35 mm e. g.)
-for veterinary or even human medicine applications
Principle of SEKELS MAGμMAN
The system consists of several different annular magnetic subsystems which are based on the so-called Halbach priciple. It employs as well Halbach-dipole as -quadrupole arrangements which generate superimposed magnetic fields and field gradients.
The homogeneous field of the dipole causes reversible agglomeration of superparamagnetic particles which increases their speed compared to single particles moved by the same gradient field.
The required magnetic field gradients are tunable in amplitude and direction by turning different quadrupole subsystems in the unit around the vertical axis. These rotations are software assisted to enable an easy adjustment of the aspired gradient configurations and thereby reproducible manipulation sequences.
The process can be observed by means of a 1:1 relay optics (Ø 16 mm) which enables adjustment of different magnifications on the employed (reflecting) microscope without the objectives to be immerged in the magnet system. The objectives can be freely adjusted on the revolver.
The screen image circle is Ø 0.6 mm and the operating distance 0.4 mm. The image is corrected for a wavelength range of 460…700 nm and diffraction limited.
Optionally we offer a 1:1 relay optics which can be immerged in liquids.
Properties
Applicable for macroscopic and nanoparticles, nanoparticle doped cells, magnetic drug targeting…
Widespread applications in life sciences, chemistry, physics…
Neglectible power consumption and heat evolution, suitable for continuous operation
Optimized for housing standard Ø 35 mm glass bottom dishes
Low construction height of only 60 mm, footprint of only 250 x 180 mm² by outsourced electronics – compatible with most transmitted light and reflecting
microscopes
Image transfer by relay optics with resolution 100…500 μm preserves focusing and lateral displacement of focus point
Homogeneous static field of 0.15 T for particle magnetization
Superimposed spatially constant Gradient field of 0…6 T/m – tunable and 360° rotatable for controlled motion of magnetized particles
Easy operation, steered by stepper motors
Including electronics and software
See also: MAGµMAN
https://www.sekels.de/en/measuring-and-magnet-systems/magmuman
This case is written by:
SEKELS GmbH
MAGNETIC MATERIALS, COMPONENTS AND SYSTEMS
SEKELS GmbH We are specialists in magnetic fields, magnetic materials, ring-shaped cores, magnetic systems and magnetic shielding - from guidance to delivery of finished components and systems.
Sekels GmbH in Ober-Mörlen, Germany
SEKELS GmbH develops, manufactures and sells technical products in the field of magnetism. With approx. 27 employees (almost half of whom are physicists and engineers) help more than 600 customers worldwide.
As a dealer for VACUUMSCHMELZE GmbH & Co. KG, we can offer our customers both an extensive stock of semi-fini